Editing 4F2 cell-surface antigen heavy chain

'''4F2 cell-surface antigen heavy chain''' (also known as '''4F2hc''' or '''CD98hc''') is a [[protein]] that in humans is encoded by the '''SLC3A2''' [[gene]]. This protein is a type II [[membrane protein]] and is a part of the [[amino acid transporter]] complex. It plays a crucial role in the regulation of [[cellular growth]] and [[differentiation]].

== Structure ==
The 4F2hc protein is a heavy chain of the heterodimeric amino acid transporters (HATs). It is a type II membrane glycoprotein and has a large extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. The extracellular domain is responsible for the interaction with the light chain subunits, while the cytoplasmic tail is involved in the regulation of [[cellular signaling]] pathways.

== Function ==
The primary function of 4F2hc is to regulate the transport of large neutral amino acids across the [[cell membrane]]. It forms a heterodimeric complex with various light chains to transport different amino acids. The 4F2hc-light chain complex is also involved in the regulation of cell growth and differentiation, and it has been implicated in various [[disease]]s, including [[cancer]] and [[neurological disorder]]s.

== Clinical significance ==
Alterations in the expression of 4F2hc have been associated with various types of cancer, including [[breast cancer]], [[lung cancer]], and [[colorectal cancer]]. Overexpression of 4F2hc has been shown to promote tumor growth and metastasis. In addition, mutations in the SLC3A2 gene have been linked to certain neurological disorders, such as [[autism]] and [[schizophrenia]].

== See also ==
* [[SLC3A2]]
* [[Amino acid transporter]]
* [[Cell membrane]]

== References ==
<references />

[[Category:Proteins]]
[[Category:Membrane proteins]]
[[Category:Cell biology]]
[[Category:Medicine]]

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