PDE5 inhibitor

PDE5 inhibitors are a class of drugs that are primarily used to treat erectile dysfunction and certain cardiovascular conditions. They work by blocking the enzyme phosphodiesterase type 5 (PDE5), which plays a crucial role in regulating blood flow to the penis and lungs.

Mechanism of Action

PDE5 inhibitors work by blocking the enzyme phosphodiesterase type 5 (PDE5). This enzyme is responsible for breaking down cyclic guanosine monophosphate (cGMP), a substance that promotes relaxation and dilation of blood vessels. By inhibiting PDE5, these drugs increase the levels of cGMP, leading to improved blood flow.

Uses

PDE5 inhibitors are primarily used to treat erectile dysfunction (ED). They can also be used to treat pulmonary arterial hypertension (PAH), a type of high blood pressure that affects the arteries in the lungs and the right side of the heart.

Side Effects

Common side effects of PDE5 inhibitors include headaches, flushing, upset stomach, and changes in vision. In rare cases, they can cause a painful erection that lasts longer than four hours, a condition known as priapism.

Examples

Examples of PDE5 inhibitors include sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra).

See Also

• Erectile Dysfunction
• Pulmonary Arterial Hypertension
• Phosphodiesterase type 5

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