Myelocyte

Myelocyte is a young cell in the granulocytic series, occurring normally in bone marrow (but not in the circulating blood), that is the precursor of the metamyelocyte and has a nucleus that is no longer round.

Overview

The myelocyte is a stage in the development of a granulocyte, following the promyelocyte, and preceding the metamyelocyte. It is characterized by the appearance of specific granules that are primary (azurophilic) granules, which are peroxidase-positive.

Development

Myelocytes are derived from promyelocytes. They are smaller than promyelocytes. They show large oval nucleus and loose chromatin. The cytoplasm is filled with specific granules (neutrophilic, eosinophilic, or basophilic). Myelocytes do not have nucleoli.

Types

There are three types of myelocytes: neutrophilic myelocytes, eosinophilic myelocytes, and basophilic myelocytes. These cells are part of the granulocyte series and are identifiable by their granules.

Function

Myelocytes are not normally found in the peripheral blood, but rather in the bone marrow. They are part of the immune system and play a role in the body's defense against infections.

Clinical significance

Abnormalities or disorders related to myelocytes can lead to diseases such as leukemia or myeloproliferative neoplasms. An increase in myelocytes (myelocytosis) can be seen in certain infections and conditions.

See also

• Hematopoiesis
• Granulopoiesis
• Myeloblast
• Promyelocyte
• Metamyelocyte

References

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  Myelocyte

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  Basophilic myelocyte

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  Eosinophilic myelocyte

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  Neutrophilic myelocyte

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  Hematopoiesis diagram