Modafinil sulfone
Modafinil sulfone is an inactive metabolite of modafinil. It is a white to off-white, crystalline powder that is practically insoluble in water and cyclohexane. It is sparingly to slightly soluble in methanol and acetone.
Pharmacology[edit]
Modafinil sulfone is a major metabolite of modafinil, which is a medication used to treat narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. Modafinil sulfone does not appear to contribute to the CNS-activating properties of modafinil.
Chemistry[edit]
Modafinil sulfone is a sulfone derivative of modafinil. It is synthesized in the liver from modafinil via the cytochrome P450 enzyme system. The chemical name for modafinil sulfone is 2-[(diphenylmethyl)sulfonyl]acetamide.
Pharmacokinetics[edit]
Following oral administration of modafinil, modafinil sulfone is one of two major metabolites detected in the plasma. The other major metabolite is modafinil acid. The pharmacokinetics of modafinil sulfone have not been fully characterized.
Clinical significance[edit]
Modafinil sulfone does not appear to contribute to the CNS-activating properties of modafinil. Therefore, it is not considered to have therapeutic relevance.
See also[edit]
References[edit]
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