- 1 Information about Levetiracetam
- 2 Liver safety of Levetiracetam
- 3 Mechanism of action of Levetiracetam
- 4 FDA approval information for Levetiracetam
- 5 Dosage and administration for Levetiracetam
- 6 Cost and Coupons - Levetiracetam
- 7 Reviews for Levetiracetam
- 8 Articles on Levetiracetam
- 9 Learn more about Levetiracetam
- 10 Help WikiMD
Information about Levetiracetam
Levetiracetam is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures.
Liver safety of Levetiracetam
Levetiracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and to rare cases of clinically apparent drug induced liver disease.
Mechanism of action of Levetiracetam
Levetiracetam (lee" ve tre ra' se tam) is a pyrrolidine derivative unrelated in structure to other anticonvulsant medications. Its mechanism of action is not known, but it is believed to act by preventing secondary spread of focal seizure activity and to decrease simultaneous neuronal firing.
FDA approval information for Levetiracetam
Levetiracetam was approved for use in epilepsy in 1999 and current indications are as adjunctive therapy for partial onset seizures, generalized tonic-clonic seizures and myoclonic seizures in both children and adults.
Dosage and administration for Levetiracetam
Levetiracetam is available as tablets of 250, 500, 750 and 1000 mg generically and under the brand name Keppra. Liquid oral and injectable forms are also available. The recommended initial dose in adults is 500 mg twice daily with dose escalation based upon tolerance and effect to a maximum of 1500 mg twice daily. Dosing in children is based upon body weight. Common side effects include dizziness, somnolence and fatigue.
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