Difference between revisions of "Gemfibrozil"

From WikiMD
Jump to navigation Jump to search
(Tag: 2017 source edit)
(Marked this version for translation)
 
Line 1: Line 1:
 
<languages />
 
<languages />
 
<translate>
 
<translate>
 +
<!--T:1-->
 
{{intro}}
 
{{intro}}
 
Clofibrate is a fibric acid derivative used in the therapy of hypertriglyceridemia and dyslipidemia.  
 
Clofibrate is a fibric acid derivative used in the therapy of hypertriglyceridemia and dyslipidemia.  
  
 +
<!--T:2-->
 
{{livtox}}
 
{{livtox}}
 
Clofibrate therapy is associated with mild and transient serum [[aminotransferase]] elevations and with rare instances of acute [[liver injury]].
 
Clofibrate therapy is associated with mild and transient serum [[aminotransferase]] elevations and with rare instances of acute [[liver injury]].
  
 +
<!--T:3-->
 
{{moa}}
 
{{moa}}
 
Clofibrate (kloe fye' brate) is a fibric acid derivative. The lipid lowering activity of clofibrate is probably mediated by its interactions with the peroxisome proliferator activated receptor alpha (PPARα), which regulates gene expression of enzymes involved in fatty acid oxidation. Clofibrate increases lipoprotein lipase levels which enhances clearance of triglyceride rich lipoproteins.  
 
Clofibrate (kloe fye' brate) is a fibric acid derivative. The lipid lowering activity of clofibrate is probably mediated by its interactions with the peroxisome proliferator activated receptor alpha (PPARα), which regulates gene expression of enzymes involved in fatty acid oxidation. Clofibrate increases lipoprotein lipase levels which enhances clearance of triglyceride rich lipoproteins.  
  
 +
<!--T:4-->
 
{{dose}}
 
{{dose}}
 
Clofibrate was available for many years and frequently used in the therapy of hypertriglyceridemia (Fredrickson types IV and V hyperlipidemia) and hyper[[cholesterol]]emia (Fredrickson types IIa and IIb).  
 
Clofibrate was available for many years and frequently used in the therapy of hypertriglyceridemia (Fredrickson types IV and V hyperlipidemia) and hyper[[cholesterol]]emia (Fredrickson types IIa and IIb).  
  
 +
<!--T:5-->
 
{{withdrawn}}
 
{{withdrawn}}
 
Use of clofibrate decreased with the availability of statins for therapy of hyperlipidemia and subsequently it was withdrawn from use in 2002. Clofibrate was available previously in generic forms and under the brand name of Atromid-S as capsules of 500 mg. The recommended dosage was 2 grams daily in divided doses.  
 
Use of clofibrate decreased with the availability of statins for therapy of hyperlipidemia and subsequently it was withdrawn from use in 2002. Clofibrate was available previously in generic forms and under the brand name of Atromid-S as capsules of 500 mg. The recommended dosage was 2 grams daily in divided doses.  
  
 +
<!--T:6-->
 
{{se}}
 
{{se}}
 
Common side effects of clofibrate include [[headache]], muscle aches and [[gastrointestinal upset]]. Fibrates have multiple drug interactions requiring careful review and use.
 
Common side effects of clofibrate include [[headache]], muscle aches and [[gastrointestinal upset]]. Fibrates have multiple drug interactions requiring careful review and use.
  
 +
<!--T:7-->
 
{{cholesterol drugs}}
 
{{cholesterol drugs}}
 
{{coststubd}}
 
{{coststubd}}
 
</translate>
 
</translate>

Latest revision as of 23:10, 15 July 2019

Other languages:
English

Information about Gemfibrozil

Clofibrate is a fibric acid derivative used in the therapy of hypertriglyceridemia and dyslipidemia.

Liver safety of Gemfibrozil

Clofibrate therapy is associated with mild and transient serum aminotransferase elevations and with rare instances of acute liver injury.

Mechanism of action of Gemfibrozil

Clofibrate (kloe fye' brate) is a fibric acid derivative. The lipid lowering activity of clofibrate is probably mediated by its interactions with the peroxisome proliferator activated receptor alpha (PPARα), which regulates gene expression of enzymes involved in fatty acid oxidation. Clofibrate increases lipoprotein lipase levels which enhances clearance of triglyceride rich lipoproteins.

Dosage and administration for Gemfibrozil

Clofibrate was available for many years and frequently used in the therapy of hypertriglyceridemia (Fredrickson types IV and V hyperlipidemia) and hypercholesterolemia (Fredrickson types IIa and IIb).

The drug Gemfibrozil was withdrawn from the US market

Use of clofibrate decreased with the availability of statins for therapy of hyperlipidemia and subsequently it was withdrawn from use in 2002. Clofibrate was available previously in generic forms and under the brand name of Atromid-S as capsules of 500 mg. The recommended dosage was 2 grams daily in divided doses.

Side effects of Gemfibrozil

Common side effects of clofibrate include headache, muscle aches and gastrointestinal upset. Fibrates have multiple drug interactions requiring careful review and use.

Lipid lowering medications

This article is a stub. YOU can help Wikimd by expanding it!

Articles on Gemfibrozil

Wikipedia

Read Wikipedia's article on Gemfibrozil

Learn more about Gemfibrozil

Apple bitten.svg

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Help WikiMD: Find something you can improve? Join WikiMD as an an editor and help improve the page Gemfibrozil or others.

Recent Articles

Most recent articles for Gemfibrozil:

Most Cited:

Review Articles:

Magazine Articles:

In the NEWS:

Scientific articles:

Clinical trials for Gemfibrozil:

Media & Blogs

Media articles for Gemfibrozil:

Books and news:

BLOGS:

Patient resources:


Social media - Gemfibrozil
Reddit
YouTube videos
Pinterest.png
Twitter.png


Frequently Asked Questions

Faq-icon.png

External articles

  • Wikipedia

Read Wikipedia's article on Gemfibrozil

Apple bitten.svg

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Help WikiMD: Find something you can improve? Join WikiMD as an an editor and help improve the page Gemfibrozil or others.