Difference between revisions of "Gemfibrozil"

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Clofibrate is a fibric acid derivative used in the therapy of hypertriglyceridemia and dyslipidemia.  
 
Clofibrate is a fibric acid derivative used in the therapy of hypertriglyceridemia and dyslipidemia.  
  
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Clofibrate therapy is associated with mild and transient serum [[aminotransferase]] elevations and with rare instances of acute [[liver injury]].
 
Clofibrate therapy is associated with mild and transient serum [[aminotransferase]] elevations and with rare instances of acute [[liver injury]].
  
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Clofibrate (kloe fye' brate) is a fibric acid derivative. The lipid lowering activity of clofibrate is probably mediated by its interactions with the peroxisome proliferator activated receptor alpha (PPARα), which regulates gene expression of enzymes involved in fatty acid oxidation. Clofibrate increases lipoprotein lipase levels which enhances clearance of triglyceride rich lipoproteins.  
 
Clofibrate (kloe fye' brate) is a fibric acid derivative. The lipid lowering activity of clofibrate is probably mediated by its interactions with the peroxisome proliferator activated receptor alpha (PPARα), which regulates gene expression of enzymes involved in fatty acid oxidation. Clofibrate increases lipoprotein lipase levels which enhances clearance of triglyceride rich lipoproteins.  
  
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Clofibrate was available for many years and frequently used in the therapy of hypertriglyceridemia (Fredrickson types IV and V hyperlipidemia) and hyper[[cholesterol]]emia (Fredrickson types IIa and IIb).  
 
Clofibrate was available for many years and frequently used in the therapy of hypertriglyceridemia (Fredrickson types IV and V hyperlipidemia) and hyper[[cholesterol]]emia (Fredrickson types IIa and IIb).  
  
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Use of clofibrate decreased with the availability of statins for therapy of hyperlipidemia and subsequently it was withdrawn from use in 2002. Clofibrate was available previously in generic forms and under the brand name of Atromid-S as capsules of 500 mg. The recommended dosage was 2 grams daily in divided doses.  
 
Use of clofibrate decreased with the availability of statins for therapy of hyperlipidemia and subsequently it was withdrawn from use in 2002. Clofibrate was available previously in generic forms and under the brand name of Atromid-S as capsules of 500 mg. The recommended dosage was 2 grams daily in divided doses.  
  
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Common side effects of clofibrate include [[headache]], muscle aches and [[gastrointestinal upset]]. Fibrates have multiple drug interactions requiring careful review and use.
 
Common side effects of clofibrate include [[headache]], muscle aches and [[gastrointestinal upset]]. Fibrates have multiple drug interactions requiring careful review and use.
  
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Latest revision as of 23:10, 15 July 2019

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Information about Gemfibrozil

Clofibrate is a fibric acid derivative used in the therapy of hypertriglyceridemia and dyslipidemia.

Liver safety of Gemfibrozil

Clofibrate therapy is associated with mild and transient serum aminotransferase elevations and with rare instances of acute liver injury.

Mechanism of action of Gemfibrozil

Clofibrate (kloe fye' brate) is a fibric acid derivative. The lipid lowering activity of clofibrate is probably mediated by its interactions with the peroxisome proliferator activated receptor alpha (PPARα), which regulates gene expression of enzymes involved in fatty acid oxidation. Clofibrate increases lipoprotein lipase levels which enhances clearance of triglyceride rich lipoproteins.

Dosage and administration for Gemfibrozil

Clofibrate was available for many years and frequently used in the therapy of hypertriglyceridemia (Fredrickson types IV and V hyperlipidemia) and hypercholesterolemia (Fredrickson types IIa and IIb).

The drug Gemfibrozil was withdrawn from the US market

Use of clofibrate decreased with the availability of statins for therapy of hyperlipidemia and subsequently it was withdrawn from use in 2002. Clofibrate was available previously in generic forms and under the brand name of Atromid-S as capsules of 500 mg. The recommended dosage was 2 grams daily in divided doses.

Side effects of Gemfibrozil

Common side effects of clofibrate include headache, muscle aches and gastrointestinal upset. Fibrates have multiple drug interactions requiring careful review and use.

Lipid lowering medications


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