Yohimbine

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Yohimbine (pronounced yo-HIM-been) is a naturally occurring substance derived from the bark of the African yohimbe tree (Pausinystalia yohimbe) and from the root of the Indian snakeroot (Rauwolfia serpentina). It is used as a dietary supplement and is commonly found in products promoting weight loss, improving athletic performance, and enhancing sexual performance.

Etymology

The term "Yohimbine" is derived from the name of the tree it is extracted from, the Yohimbe tree. The tree's name, in turn, is believed to have originated from the Bantu languages of West Africa.

Pharmacology

Yohimbine acts as an alpha-2 adrenergic antagonist, which means it inhibits the action of the alpha-2 adrenergic receptors. This results in an increase in the release of norepinephrine, a hormone that can stimulate the nervous system and increase heart rate. It is also known to increase blood flow and is therefore often used in treatments for erectile dysfunction.

Medical Uses

Yohimbine has been used in the treatment of erectile dysfunction and as a weight loss supplement. It is also used in veterinary medicine to reverse sedation in dogs and deer.

Side Effects

Common side effects of yohimbine include increased heart rate, high blood pressure, anxiety, dizziness, and sleep problems. It is advised to consult a healthcare provider before starting any supplement regimen, especially for those with underlying health conditions.

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