WikiMD is the world's largest medical encyclopedia with
28,900 pages, 4,107,262 edits & 35,688,120 views.
Vemurafenib
Information about Vemurafenib
Vemurafenib is a selective inhibitor of BRAF kinase that is used in the therapy of patients with metastatic and advanced malignant melanoma.
Liver safety of Vemurafenib
Vemurafenib therapy is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe cases of clinically apparent acute liver injury.
Mechanism of action of Vemurafenib
Vemurafenib (vem’ ue raf” e nib) is an orally available inhibitor of mutated forms of BRAF, a serine/threonine kinase that is a component of the mitogen-activated pathway (MAP) kinases which are important intracellular signals involved in control of cell growth and proliferation. BRAF kinase is an early step in the cascade of MAP kinases (RAS-RAF-MEK-ERK) and is frequently mutated in malignant conditions, including at least half of cases of melanoma. Vemurafenib was shown to be active against the V600E mutants of BRAF in vitro and in animal models. Furthermore, in clinical trials vemurafenib therapy was associated with an improvement in overall survival in patients with metastatic malignant melanoma with V600E mutations.
FDA approval information for Vemurafenib
Vemurafenib was approved for use in the United States in 2011 and current indications are for unresectable or metastatic melanoma with the BRAF V600E mutation and Langerhans-cell histiocytosis with BRAF V600 mutations.
Dosage and administration for Vemurafenib
Vemurafenib is available in tablets of 240 mg under the brand name Zelboraf. The typical dose is 960 mg (4 tablets) twice daily.
Side effects of Vemurafenib
Common side effects include fatigue, nausea, arthralgias, rash, alopecia, photosensitivity, pruritus, and skin papilloma. Uncommon, but potentially severe side effects include severe skin and hypersensitivity reactions (including Stevens Johnson syndrome), cutaneous squamous cell carcinoma, ocular toxicity, and prolonged QTc intervals. Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ
Cost and Coupons - Vemurafenib
- GoodRx compare cost & coupons for Vemurafenib
- Find the lowest cost of Vemurafenib
- Search for Coupons for Vemurafenib
Reviews for Vemurafenib
Learn more about Vemurafenib
- Dailymed label info
- Scientific articles
- Drug portal Vemurafenib
- toxicity info on Vemurafenib
- FDA Vemurafenib
Latest research (Pubmed)
External links
WikiMD needs you!
This WikiMD article Vemurafenib is a stub.
If you are a healthcare professional familiar with the topic Vemurafenib, or
A subject matter expert or authority on Vemurafenib, you can help us.
About | Mission | Paid editors welcome!
| Vemurafenib is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever! |
|---|
| Medicine: Health - Encyclopedia - Topics - Diseases - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers |
 Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP* |
