Tyramine

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Tyramine

Tyramine (pronounced /ˈtaɪrəmiːn/) is a naturally occurring monoamine compound and trace amine derived from the amino acid tyrosine. Tyramine acts as a catecholamine releasing agent. It is unable to cross the blood-brain barrier, resulting in non-psychoactive peripheral sympathomimetic effects following ingestion. A hypertensive crisis can result, however, from ingestion of tyramine-rich foods in conjunction with monoamine oxidase inhibitors (MAOIs).

Etymology

The term "tyramine" is derived from tyros, the Greek word for cheese, as it was first discovered in cheese. The suffix "-amine" indicates its classification as an amine, a basic nitrogenous compound.

Related Terms

  • Tyrosine: An amino acid that is used by cells to synthesize proteins. It is the precursor of tyramine.
  • Catecholamine: A group of hormones produced in the body that include epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine.
  • Sympathomimetic: Drugs that mimic the effects of the sympathetic nervous system.
  • Monoamine oxidase inhibitors (MAOIs): A class of drugs that inhibit the activity of one or both monoamine oxidase enzymes, used in the treatment of depression or Parkinson's disease.

See Also

External links

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