Tumor metabolome

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Tumor Metabolome

The Tumor Metabolome (pronunciation: /ˈtjuːmər ˌmetəˈboʊloʊm/) is the complete set of metabolites, which are small molecules present in a tumor cell, and the changes these metabolites undergo during cancer progression.

Etymology

The term "Tumor Metabolome" is derived from the words "tumor", which originates from the Latin word 'tumere' meaning to swell, and "metabolome", which is a combination of "metabolism" and "-ome", a suffix used to denote a complete set in biological sciences.

Related Terms

  • Metabolomics: The large-scale study of small molecules, commonly known as metabolites, within cells, biofluids, tissues, or organisms.
  • Metabolite: A substance necessary for or taking part in a particular metabolic process.
  • Tumor: An abnormal mass of tissue that results when cells divide more than they should or do not die when they should.
  • Cancer: A group of diseases characterized by the uncontrolled growth and spread of abnormal cells.
  • Oncology: The study and treatment of tumors.

Understanding Tumor Metabolome

The tumor metabolome is a reflection of the physiological state of a cancer cell and can provide valuable insights into the metabolic alterations that occur during cancer progression. These alterations can be due to changes in the expression of genes involved in metabolic pathways, or due to changes in the availability of nutrients in the tumor microenvironment.

The study of the tumor metabolome can help in the identification of novel biomarkers for cancer diagnosis and prognosis, and can also provide targets for therapeutic intervention. For example, certain metabolites may be found at elevated levels in the blood or urine of cancer patients, and these can be used as biomarkers for early detection of cancer.

The tumor metabolome can also provide insights into the mechanisms of drug resistance in cancer. Some cancer cells can alter their metabolism in response to drug treatment, and this can lead to drug resistance. By studying the changes in the tumor metabolome during drug treatment, it may be possible to identify new strategies to overcome drug resistance.

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