Tumor M2-PK

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Tumor M2-PK

Tumor M2-PK (pronounced: too-mor em-two-pee-kay), also known as M2 Pyruvate Kinase is a type of enzyme that is found in the human body. It is a key player in the metabolism of glucose, which is the main source of energy for the body's cells.

Etymology

The term "Tumor M2-PK" is derived from the words "tumor", which refers to an abnormal growth of tissue, and "M2-PK", which is an abbreviation for "M2 Pyruvate Kinase". The "M2" refers to the M2 isoform of the enzyme pyruvate kinase, which is often found in rapidly dividing cells, such as cancer cells.

Function

Tumor M2-PK plays a crucial role in the Warburg effect, a phenomenon observed in most cancer cells where they preferentially metabolize glucose by glycolysis despite the presence of oxygen. This is in contrast to normal cells, which primarily produce energy through a process called oxidative phosphorylation when oxygen is present.

Clinical Significance

The level of Tumor M2-PK in the blood can be used as a biomarker for the presence of cancer. A high level of this enzyme in the blood is often associated with the presence of a malignant tumor. Therefore, measuring the level of Tumor M2-PK can be useful in the early detection of cancer.

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