Trough level
Trough Level
Trough level (pronunciation: /trɔf levəl/), also known as nadir level, is a term used in pharmacokinetics to refer to the lowest concentration of a drug in the body's circulation. It is typically measured immediately before the administration of the next dose of the drug.
Etymology
The term "trough level" originates from the English word "trough", which refers to a low point or a valley. In the context of pharmacokinetics, it refers to the lowest point or level of a drug's concentration in the body.
Related Terms
- Peak level: The highest concentration of a drug in the body's circulation, typically measured a certain period after the drug is administered.
- Half-life: The time it takes for the concentration of a drug in the body to reduce by half.
- Therapeutic window: The range of drug concentrations in the body that are effective without being harmful.
- Pharmacodynamics: The study of the biochemical and physiological effects of drugs and their mechanisms of action.
- Pharmacokinetics: The study of how the body absorbs, distributes, metabolizes, and excretes drugs.
See Also
External links
- Medical encyclopedia article on Trough level
- Wikipedia's article - Trough level
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