Troponin T
Troponin T
Troponin T (/trɒˈpoʊnɪn ˈtiː/) is a protein that is integral to the contraction of skeletal and heart muscle. It is one of three subunits that make up the troponin complex, the others being Troponin I and Troponin C.
Etymology
The term "Troponin" is derived from the Greek words "tropos" meaning "turn" and "ninos" meaning "sinew". The "T" in Troponin T stands for "tropomyosin", the protein to which it binds.
Function
Troponin T binds to tropomyosin, positioning it on the actin filament, which is crucial for muscle contraction. It also binds to Troponin I, inhibiting the actin-myosin interaction. When calcium binds to Troponin C, it causes a conformational change in the troponin complex, allowing the actin-myosin interaction and thus muscle contraction.
Clinical significance
In the medical field, Troponin T is often used as a diagnostic marker for heart damage, such as a myocardial infarction. Elevated levels of Troponin T in the blood can indicate damage to the heart muscle, as it is released into the bloodstream when there is damage to the heart.
Related terms
- Troponin I: Another subunit of the troponin complex, it binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place.
- Troponin C: The third subunit of the troponin complex, it binds to four calcium ions to initiate muscle contraction.
- Tropomyosin: A protein that binds to actin filaments and regulates muscle contraction.
- Myocardial infarction: Commonly known as a heart attack, it is a medical condition where blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.
External links
- Medical encyclopedia article on Troponin T
- Wikipedia's article - Troponin T
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