Troponin I

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Troponin I

Troponin I (pronounced: troh-POH-nin eye) is a protein that is found in heart muscle cells. It is part of the troponin complex, which is involved in the regulation of muscle contraction.

Etymology

The term "Troponin I" is derived from the Greek words "tropos" meaning "turn" and "ninos" meaning "sinew". The "I" stands for "inhibitory", as Troponin I inhibits muscle contraction in the absence of calcium.

Function

Troponin I is a part of the troponin complex, which also includes Troponin T and Troponin C. This complex is attached to the protein tropomyosin, which is located on the actin filament in muscle cells. When calcium binds to Troponin C, it causes a conformational change in the troponin complex, which allows tropomyosin to move and expose the binding sites for myosin on the actin filament. This initiates muscle contraction.

Clinical significance

In the event of a heart attack, heart muscle cells are damaged and Troponin I is released into the bloodstream. Therefore, the level of Troponin I in the blood is a useful indicator of heart muscle damage. A high level of Troponin I in the blood is a strong indicator of a recent heart attack.

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