Transient neonatal pustular melanosis

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Transient Neonatal Pustular Melanosis

Transient Neonatal Pustular Melanosis (pronunciation: tran-zee-uhnt nee-oh-nay-tl pus-chuh-lur mel-uh-noh-sis) is a benign, self-limiting skin condition that presents at birth or in the early neonatal period. It is characterized by small, sterile pustules, which soon rupture to leave pigmented macules.

Etymology

The term "Transient Neonatal Pustular Melanosis" is derived from the Latin transiens (passing over), neonatus (newborn), and pustula (pimple), and the Greek melas (black) and -osis (condition).

Clinical Presentation

Transient Neonatal Pustular Melanosis presents as small vesicopustules or pigmented macules. The vesicopustules are filled with a sterile, yellowish fluid and are most commonly found on the chin, neck, back, and extremities. The pigmented macules, which are brown to black in color, appear after the rupture of the vesicopustules and can persist for several months.

Diagnosis

The diagnosis of Transient Neonatal Pustular Melanosis is primarily clinical, based on the characteristic appearance of the skin lesions. A skin biopsy is rarely necessary but, if performed, shows intraepidermal vesicles filled with neutrophils and melanophages in the dermis.

Treatment

No treatment is necessary for Transient Neonatal Pustular Melanosis as the condition is self-limiting. The pigmented macules gradually fade over a period of weeks to months.

Epidemiology

Transient Neonatal Pustular Melanosis is more common in African-American infants but can occur in infants of any race. It is also slightly more common in female infants.

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