Information about Tolterodine
Liver safety of Tolterodine
Tolterodine has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
Mechanism of action of Tolterodine
Tolterodine (tol ter' oh deen) is a synthetic anticholinergic and antispasmotic agent that inhibits muscarinic actions of acetylcholine on autonomic nerve endings, decreasing secretions and inhibiting gastrointestinal and bladder motility. Tolterodine increases bladder capacity and decreases bladder contractions and the urgency of urination.
FDA approval information for Tolterodine
Tolterodine was approved for use in the United States in 1998 and indications include urge incontinence and overactive bladder syndrome, including symptoms of urinary urgency and frequency.
Dosage and administration for Tolterodine
Tolterodine is available in tablets of 1 and 2 mg and as extended release capsules of 2 and 4 mg in generic forms and under the brand name Detrol. The recommended adult oral dose is 2 to 4 mg daily.
Side effects of Tolterodine
Common side effects are those of parasympathetic stimulation and include dryness of the mouth and eyes, decreased sweating, headache, visual blurring, constipation, urinary retention, restlessness, confusion and hallucinations. anticholinergic agents can precipitate acute narrow angle glaucoma and acute urinary retention.
- Overactive bladder syndrome agents - darifenacin, fesoterodine, flavoxate, hyoscyamine, mirabegron, oxybutynin, solifenacin, tolterodine, trospium
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