TMD
| TMD | |
|---|---|
| Term | TMD |
| Short definition | TMD - A disease of the bone marrow that can occur in newborn babies with Down syndrome. It is characterized by abnormal, immature haematopoietic cells in the blood and bone marrow (particularly the cells involved in the formation of platelets). |
| Type | Cancer terms |
| Specialty | Oncology |
| Language | English |
| Source | NCI |
| Comments | |
TMD - A disease of the bone marrow that can occur in newborn babies with Down syndrome. It is characterized by abnormal, immature haematopoietic cells in the blood and bone marrow (particularly the cells involved in the formation of platelets). The liver may also be larger than normal. TMD is caused by mutations (changes) in a gene called GATA1. TMD usually goes away on its own within the first 3 months of life. Sometimes TMD causes serious or life-threatening problems, such as bleeding problems, infections, heart, kidney, and liver failure, and abnormal buildup of fluid in the tissues that cover organs in the body. Infants with TMD have an increased risk of developing acute myeloid leukemia (AML) before the age of 3 years. Also referred to as TAM, Transient Abnormal Myelopoiesis, Transient Leukemia, and Transient Myeloproliferative Disorder
External links
- Medical encyclopedia article on TMD
- Wikipedia's article - TMD
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