Tight junction
Tight junction
Tight junction (pronunciation: /taɪt ˈdʒʌŋkʃən/) is a type of cell-to-cell adhesion that forms a barrier to prevent substances from moving freely between the intercellular space.
Etymology
The term "tight junction" was coined due to the close proximity of the cells involved, which are so close that they appear to be "tightly" joined together.
Definition
Tight junctions are a type of cell junction that seals adjacent epithelial cells together, forming a virtually impermeable barrier to fluid. They are crucial in maintaining the distinct environments of various body compartments.
Structure
Tight junctions are composed of a complex network of proteins, including claudins, occludin, and junctional adhesion molecules (JAMs). These proteins interact with each other and with the cytoskeleton to form the tight junction structure.
Function
The primary function of tight junctions is to prevent the passage of molecules and ions through the space between cells. They also help to maintain cell polarity by preventing the lateral diffusion of proteins and lipids in the plasma membrane.
Related terms
See also
External links
- Medical encyclopedia article on Tight junction
- Wikipedia's article - Tight junction
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