Tigecycline

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Tigecycline

Tigecycline (pronounced: tie-ge-sye-kleen) is a glycylcycline antibiotic used in the treatment of a variety of bacterial infections. It is a derivative of tetracycline, and is often used when other antibiotics are ineffective.

Etymology

The name "Tigecycline" is derived from its chemical structure, which includes a "tiger" (tige) and a "cycline" (cycline), referring to its classification as a glycylcycline antibiotic.

Usage

Tigecycline is used to treat a variety of bacterial infections, including skin infections, intra-abdominal infections, and community-acquired pneumonia. It is particularly effective against multi-drug resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).

Mechanism of Action

Tigecycline works by inhibiting protein synthesis in bacteria, preventing them from growing and multiplying. It does this by binding to the 30S ribosomal subunit, a part of the bacterial cell's machinery for making proteins.

Side Effects

Common side effects of tigecycline include nausea, vomiting, and diarrhea. More serious side effects can include pancreatitis, liver damage, and an increased risk of death in certain patients.

Related Terms

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