Logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
28,900 pages, 4,107,262 edits & 35,688,120 views.

Free unbiased diet, health and wellness info!

Thiotepa

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search


Information about Thiotepa

Thiotepa is an intravenously or locally applied or injected alkylating agent which is currently used in the therapy of breast, ovarian and bladder cancer and for Hodgkin disease

Liver safety of Thiotepa

Thiotepa therapy has been associated with low rates of serum enzyme elevations during therapy and very rare instances of acute, clinically apparent injury.

Mechanism of action of Thiotepa

Thiotepa (thye' oh tep' a) is an ethylenimine similar in structure and activity to altretamine and is believed to act as an alkylating agent.  The alkylating agents act by causing modification and cross linking of DNA, thus inhibiting DNA, RNA and protein synthesis and causing programmed cell death (apoptosis) in rapidly dividing cells. 

FDA approval information for Thiotepa

Thiotepa was approved for use in the United States in 1959.  Current indications include ovarian and breast cancer and Hodgkin disease.  Thiotepa is also administered locally for bladder cancer, neoplastic effusions and malignant meningeal neoplasms. 

Dosage and administration for Thiotepa

Thiotepa is available generically in vials of 15 mg.  The dose recommended doses varies by indications, route of administration, and body weight. 

Side effects of Thiotepa

Thiotepa shares common side effects with other alkylating agents such as nausea, vomiting, diarrhea, alopecia, bone marrow suppression, rash and hypersensitivity reactions.

Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ

Learn more about Thiotepa

Latest research (Pubmed)

PubMed
Wikipedia

External links


edit 

WikiMD needs you!

This WikiMD article Thiotepa is a stub.
If you are a healthcare professional familiar with the topic Thiotepa, or
A subject matter expert or authority on Thiotepa, you can help us.
About | Mission | Paid editors welcome!

Thiotepa is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever!
Medicine: Health - Encyclopedia‏‎‏‎ - Topics‏‎ -‏‎ Diseases‏‎ - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity‏‎ - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP*
Special: W8MD's tele-weight loss consultations only $99.99. Call 718-946-5500. Limited acceptance.