Tenecteplase
Tenecteplase
Tenecteplase (pronounced as te-nek-te-plase) is a thrombolytic agent, specifically a modified version of the enzyme tissue plasminogen activator (tPA). It is used in the treatment of myocardial infarction (heart attack).
Etymology
The term "Tenecteplase" is derived from the combination of "teneo" (Latin for "to hold") and "ecteplase" (a modified form of tPA). The "ten" in Tenecteplase refers to the ten amino acid changes that differentiate it from the natural tPA.
Usage
Tenecteplase is used in the treatment of acute myocardial infarction (AMI), more commonly known as a heart attack. It works by breaking down blood clots that have formed in the blood vessels of the heart, thereby restoring blood flow to the affected area.
Mechanism of Action
Tenecteplase is a fibrinolytic agent, meaning it breaks down fibrin, the main component of blood clots. It does this by converting plasminogen, a protein found in blood, into plasmin, an enzyme that breaks down fibrin.
Related Terms
- Thrombolysis: The process of breaking down blood clots in the blood vessels.
- Fibrin: A protein that forms the structure of blood clots.
- Plasminogen: A protein in the blood that is converted into plasmin by fibrinolytic agents like Tenecteplase.
- Plasmin: An enzyme that breaks down fibrin, thereby dissolving blood clots.
See Also
External links
- Medical encyclopedia article on Tenecteplase
- Wikipedia's article - Tenecteplase
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