Tamoxifen citrate

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Tamoxifen citrate

Tamoxifen citrate (pronunciation: ta-MOX-i-fen SIT-rate) is a medication primarily used in the treatment and prevention of breast cancer. It belongs to a class of drugs known as selective estrogen receptor modulators (SERMs).

Etymology

The name "Tamoxifen" is derived from its developer, Imperial Chemical Industries (ICI), which later became part of AstraZeneca. The "tam" part of the name comes from the compound's original code name, "TAM", while "oxifen" is derived from its chemical structure, which is an oxime ether of an ethylenediamine derivative.

Usage

Tamoxifen citrate is used to treat both early and advanced estrogen receptor-positive (ER-positive) breast cancer in pre- and post-menopausal women. It is also used to reduce the risk of developing breast cancer in those who are at high risk.

Mechanism of Action

Tamoxifen citrate works by binding to estrogen receptors in breast cells, blocking the effects of estrogen, a hormone that can promote the growth of breast cancer cells.

Side Effects

Common side effects of Tamoxifen citrate include hot flashes, nausea, and fatigue. More serious side effects can include blood clots, stroke, and endometrial cancer.

Related Terms

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