Tamibarotene

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Tamibarotene (pronunciation: tah-mee-bah-roh-teen) is a synthetic retinoid, derived from vitamin A. It is primarily used in the treatment of acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML).

Etymology

The term "Tamibarotene" is derived from the Japanese word "Tamibaro", which means "to change or transform", and the suffix "-tene", which is commonly used in the nomenclature of retinoids.

Pharmacology

Tamibarotene works by binding to and activating the retinoic acid receptor (RAR), specifically RARα and RARβ. This leads to the differentiation and apoptosis of leukemic cells, thereby reducing the number of immature cells in the blood and bone marrow.

Clinical Use

Tamibarotene is used as a treatment for APL, particularly in patients who have relapsed or are refractory to all-trans retinoic acid (ATRA). It has been shown to be more potent and less toxic than ATRA in preclinical studies.

Side Effects

Common side effects of Tamibarotene include dry skin, bone pain, nausea, and vomiting. More serious side effects can include liver damage, high cholesterol, and pancreatitis.

Related Terms

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