T-cell depletion

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T-cell Depletion

T-cell depletion (pronunciation: tee-sell dee-plee-shun) is a medical procedure that involves the removal or reduction of T-cells from the body. This process is often used in hematopoietic stem cell transplantation to prevent graft-versus-host disease (GVHD).

Etymology

The term "T-cell depletion" is derived from the name of the type of white blood cell, the T-cell, which is targeted in this procedure. The word "depletion" comes from the Latin word "deplere", meaning "to empty out".

Procedure

T-cell depletion is performed using various methods, including immunomagnetic separation, complement-mediated lysis, and monoclonal antibody-based techniques. The goal is to reduce the number of T-cells in the donor's stem cell graft to prevent the occurrence of GVHD after transplantation.

Applications

T-cell depletion is primarily used in the context of hematopoietic stem cell transplantation. It is particularly beneficial for patients who are at high risk of developing GVHD, such as those receiving transplants from mismatched or unrelated donors. T-cell depletion can also be used in the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, by reducing the number of autoreactive T-cells.

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