Sulfonylureas

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Sulfonylureas

Sulfonylureas (pronounced: sul-foh-nil-yoo-ree-uhs) are a class of antidiabetic medications that are used in the management of diabetes mellitus type 2. They act by increasing insulin release from the beta cells in the pancreas.

Etymology

The term "sulfonylurea" is derived from its chemical structure, which consists of a sulfonyl group attached to a urea. Sulfonylureas were among the first oral medications available for the treatment of type 2 diabetes.

Types of Sulfonylureas

There are several types of sulfonylureas, including:

Mechanism of Action

Sulfonylureas work by binding to specific receptors on the beta cells in the pancreas, which leads to an increase in insulin release. This increased insulin helps to lower blood glucose levels.

Side Effects

Common side effects of sulfonylureas include hypoglycemia, weight gain, and skin rash. Less common side effects can include gastrointestinal upset and liver disease.

Related Terms

External links

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