Streptokinase

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Streptokinase

Streptokinase (pronunciation: strep-toe-KYE-nase) is a type of enzyme that is used as a medication to break down blood clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism.

Etymology

The term "Streptokinase" is derived from the genus Streptococcus from which it was first isolated, and the suffix "-kinase" indicating its enzymatic activity. The Streptococcus genus is a group of Gram-positive bacteria that includes several pathogenic species.

Mechanism of Action

Streptokinase works by converting plasminogen to plasmin, the enzyme responsible for breaking down blood clots. This process is known as fibrinolysis.

Usage

Streptokinase is used in the treatment of conditions caused by blood clots, such as heart attacks and pulmonary embolisms. It is administered intravenously in a hospital setting.

Side Effects

Potential side effects of streptokinase include bleeding, allergic reactions, and fever. It is contraindicated in patients with a history of hemorrhagic stroke, recent surgery, or active bleeding.

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