Stavudine

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Information about Stavudine

Stavudine is a nucleoside analogue and reverse transcriptase inhibitor used in combination with other agents in the therapy of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS).

Liver safety of Stavudine

Stavudine is an uncommon, but well established cause of clinically apparent acute liver injury.

Mechanism of action of Stavudine

Stavudine (stav' ue deen) is a synthetic thymidine analogue (2’,3’-didehydro-2’3’- dideoxydeoxythymidine: d4T) that inhibits HIV replication by competing with naturally occurring thymidine for incorporation into the growing viral DNA chain, causing inhibition of the viral polymerase (reverse transcriptase) and chain termination. Stavudine was approved for use in the treatment of HIV infection in the United States in 1994 and was widely used in many antiretroviral regimens for many years. Recently, stavudine has been replaced by other better tolerated nucleoside analogues and is no longer commonly used in developed countries. It is, however, still used in resource limited settings.

Dosage and administration for Stavudine

Stavudine is available in multiple generic forms and under the brand name Zerit in 15, 20, 30, and 40 mg capsules. Oral solutions of stavudine (1 mg/mL) are also available. The recommended dose of stavudine is 30 to 40 mg orally every 12 hours in adults and in children greater than 30 kg.

Side effects of Stavudine

Common side effects include diarrhea, headache, macrocytosis, nausea and vomiting, peripheral neuropathy and rash.

Antiviral agents

Drugs for HIV Infection, in the Subclass Antiretroviral Agents

Drugs for Hepatitis B

Drugs for Hepatitis C

HCV NS5A Inhibitors

HCV NS5B (Polymerase) Inhibitors

HCV Protease Inhibitors

Combination Therapies

Drugs for Herpes Virus Infections (HSV, CMV, others)

Drugs for Influenza

Cost and Coupons - Stavudine

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