Splicing
Splicing
Splicing (/ˈsplɪsɪŋ/) is a fundamental process in the molecular biology field that involves the removal of introns and joining of exons in a pre-mRNA molecule. This process is crucial for the proper expression of genes and the production of functional proteins.
Etymology
The term 'splicing' originates from the English word 'splice', which means to join or connect. In the context of molecular biology, it refers to the joining of exons and the removal of introns from a pre-mRNA molecule.
Process
Splicing occurs in the nucleus of a cell and is facilitated by a large complex known as the spliceosome. The spliceosome recognizes specific sequences at the 5' and 3' ends of the intron, cuts the intron out, and then joins the two exons together. This process results in a mature mRNA molecule that can be translated into a protein by the ribosome.
Types of Splicing
There are two main types of splicing: alternative splicing and constitutive splicing. In alternative splicing, different combinations of exons are joined together, resulting in different mRNA molecules and, consequently, different proteins. In constitutive splicing, the same exons are always joined together.
Related Terms
See Also
External links
- Medical encyclopedia article on Splicing
- Wikipedia's article - Splicing
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