Sirolimus - a natural macrocyclic lactone produced by the bacterium streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin fk binding protein-12 (fkbp-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian target of rapamycin (mtor), a key regulatory kinase. This results in inhibition of t lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (il-2, il-4, and il-15) stimulation and inhibition of antibody production. sirolimus
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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Sirolimus for any updates.