Sincalide

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Sincalide

Sincalide (/sɪnˈkælaɪd/) is a choleretic and cholecystokinetic agent that is used in diagnostic procedures to assess gallbladder function and to treat certain gastrointestinal disorders.

Etymology

The term "sincalide" is derived from the words "synthetic" and "cholecystokinin", referring to its synthetic nature and its similarity to the natural hormone cholecystokinin.

Usage

Sincalide is used in a cholecystokinin provocation test, which is a diagnostic procedure used to assess the function of the gallbladder and the sphincter of Oddi. It is also used to treat certain gastrointestinal disorders, such as chronic idiopathic constipation and irritable bowel syndrome.

Mechanism of Action

Sincalide works by stimulating the contraction of the gallbladder and the release of bile into the small intestine. It also slows gastric emptying and increases the secretion of water and electrolytes into the intestines.

Related Terms

  • Cholecystokinin: A hormone that stimulates the release of bile from the gallbladder.
  • Choleretic: A substance that increases the production of bile.
  • Cholecystokinetic: A substance that stimulates the contraction of the gallbladder.
  • Sphincter of Oddi: A muscular valve that controls the flow of digestive juices (bile and pancreatic juice) to the duodenum.
  • Chronic idiopathic constipation: A gastrointestinal disorder characterized by persistent, difficult, infrequent, or seemingly incomplete defecation.
  • Irritable bowel syndrome: A common disorder that affects the large intestine and can cause cramping, abdominal pain, bloating, gas, diarrhea, and constipation.

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