Simtuzumab
Simtuzumab
Simtuzumab (pronunciation: sim-too-zoo-mab) is a monoclonal antibody designed for the treatment of fibrosis and certain types of cancer.
Etymology
The name "Simtuzumab" is derived from the International Nonproprietary Names (INN), where "sim-" refers to the company that developed the drug (Gilead Sciences), "-tuz-" is a stem used for tumor treatment, and "-mab" is a suffix for monoclonal antibodies.
Usage
Simtuzumab was developed by Gilead Sciences for the treatment of idiopathic pulmonary fibrosis and pancreatic cancer. It works by targeting and inhibiting LOXL2, a protein that contributes to the stiffening of tissue, a characteristic feature of fibrotic diseases and solid tumors.
Clinical Trials
Simtuzumab has undergone several clinical trials to evaluate its safety and efficacy. However, the trials did not meet their primary endpoints, and the development of the drug was discontinued.
Related Terms
- Monoclonal antibody: A type of protein made in the lab that can bind to substances in the body, including cancer cells.
- Fibrosis: The thickening and scarring of connective tissue, usually as a result of injury.
- Cancer: A group of diseases characterized by the uncontrolled growth and spread of abnormal cells.
- Gilead Sciences: A biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need.
- Idiopathic pulmonary fibrosis: A type of chronic lung disease characterized by a progressive and irreversible decline in lung function.
- Pancreatic cancer: A disease in which malignant (cancer) cells form in the tissues of the pancreas.
- Clinical trials: Research studies that involve people. They test whether drugs, therapies, medical procedures, or devices are safe and effective.
External links
- Medical encyclopedia article on Simtuzumab
- Wikipedia's article - Simtuzumab
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