Sertindole
Sertindole
Sertindole (pronounced: ser-tin-dole) is an atypical antipsychotic medication primarily used in the treatment of schizophrenia. It is a non-sedating antipsychotic and has a unique receptor profile.
Etymology
The term "Sertindole" is derived from its chemical name, which is 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one.
Pharmacology
Sertindole is a potent antagonist at dopamine D2 receptors, serotonin 5-HT2 receptors and alpha 1-adrenoceptors. It has a high affinity for dopamine D2 and D3 receptors, and serotonin 5-HT2A and 5-HT2C receptors.
Clinical Use
Sertindole is used in the treatment of schizophrenia. It is particularly effective in managing the negative symptoms of schizophrenia, such as apathy and withdrawal.
Side Effects
Common side effects of Sertindole include dizziness, headache, insomnia, and constipation. In rare cases, it can cause serious cardiac side effects, including QT interval prolongation.
Related Terms
- Atypical antipsychotic
- Schizophrenia
- Dopamine D2 receptor
- Serotonin 5-HT2 receptor
- Alpha 1-adrenoceptor
- QT interval
External links
- Medical encyclopedia article on Sertindole
- Wikipedia's article - Sertindole
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