Serotonin transporter
Serotonin Transporter
The Serotonin Transporter (SERT or 5-HTT) is a type of membrane transport protein that transports serotonin from the synaptic cleft back into the presynaptic neuron. This process is known as reuptake, and it terminates the action of serotonin at the synapse. The pronunciation of Serotonin Transporter is /sɛrəˈtoʊnɪn trænˈspɔːrtər/.
Etymology
The term "Serotonin Transporter" is derived from the neurotransmitter serotonin, which was first identified in 1948 and is derived from the Greek words "sero-" (serum) and "tonin" (derived from "tone," indicating influence over). The term "transporter" refers to the protein's role in transporting serotonin molecules.
Function
The Serotonin Transporter plays a crucial role in regulating the concentration of serotonin in the synaptic cleft. By transporting serotonin back into the presynaptic neuron, it effectively terminates the action of serotonin and allows for the recycling of this important neurotransmitter. This process is essential for maintaining normal serotonin levels and ensuring proper neurotransmission.
Related Terms
- Selective serotonin reuptake inhibitors (SSRIs): A class of drugs that inhibit the reuptake of serotonin by blocking the action of the serotonin transporter. This increases the amount of serotonin available in the synaptic cleft, which can help to alleviate symptoms of depression and anxiety.
- Serotonin syndrome: A potentially life-threatening condition that can occur following an overdose of serotonin-enhancing drugs, such as SSRIs. Symptoms can include agitation, restlessness, and rapid heart rate.
- Neurotransmitter: Chemicals that transmit signals from one neuron to another. Serotonin is one such neurotransmitter, and it is primarily found in the gastrointestinal tract, blood platelets, and the central nervous system.
External links
- Medical encyclopedia article on Serotonin transporter
- Wikipedia's article - Serotonin transporter
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