Selective IgA deficiency
Selective IgA Deficiency
Selective IgA Deficiency (si-ˈlek-tiv \ ī-ˈjē-ˈā \ di-ˈfi-shən-sē) is a genetic disorder characterized by a decrease or complete absence of immunoglobulin A (IgA) antibodies in the body. This condition is one of the most common primary immunodeficiency disorders.
Etymology
The term "Selective IgA Deficiency" is derived from the words "selective", indicating a specific focus, and "IgA", an abbreviation for immunoglobulin A, a type of antibody that plays a crucial role in the immune response of the mucous membranes. "Deficiency" refers to the lack or shortage of something.
Definition
Selective IgA Deficiency is a condition in which the body produces insufficient amounts of IgA antibodies, leading to an increased susceptibility to infections, particularly in the respiratory tract, gastrointestinal tract, and genitourinary tract.
Symptoms
Symptoms of Selective IgA Deficiency can vary widely among individuals. Some people may remain asymptomatic, while others may experience recurrent sinusitis, pneumonia, ear infections, and diarrhea. There is also an increased risk of developing autoimmune diseases, allergies, and asthma.
Diagnosis
Diagnosis of Selective IgA Deficiency typically involves blood tests to measure the levels of different types of immunoglobulins. A diagnosis is confirmed when IgA levels are significantly lower than normal, while levels of other immunoglobulins are normal.
Treatment
There is currently no cure for Selective IgA Deficiency. Treatment primarily focuses on managing symptoms and preventing infections. This may involve the use of antibiotics to treat or prevent infections, and immunoglobulin therapy may be considered in some cases.
Related Terms
External links
- Medical encyclopedia article on Selective IgA deficiency
- Wikipedia's article - Selective IgA deficiency
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