Selective Estrogen Receptor Modulators

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Information about Selective Estrogen Receptor Modulators

The selective estrogen receptor modulators (SERMs) are a group of nonsteroidal compounds that have estrogen-like effects (agonism) on some tissues (such as bone, skin, heart or vaginal epithelium), but antiestrogen effects (antagonism) on other tissues (such as breast or uterus).  Depending on the tissue specificity and balance of the agonist and antagonist activities, these agents have different clinical effects, different indications and different adverse side effects

Clinical use of Selective Estrogen Receptor Modulators

Typical indications for SERMS include treatment or prevention of breast cancer (tamoxifen, toremifene, raloxifene), treatment or prevention of postmenopausal osteoporosis (raloxifene, bazedoxifene) and amelioration of symptoms of menopause symptoms (ospemifene).  Separate documents for the SERMs that are used largely for prevention of cancer.  SERMs used for treatment of nonmalignant conditions such as osteoporosis and menopausal symptoms of hot flashes and dyspareunia. 

Drug class for Selective Estrogen Receptor Modulators

antineoplastic agents, Osteoporosis Agents

List of SERMS

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Medication resources

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