Saxagliptin

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Information about Saxagliptin

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other oral hypoglycemic agents.

Template:Livto Saxagliptin is a relatively new medication and has yet to be implicated in causing clinically apparent liver injury.

Mechanism of action of Saxagliptin

Saxagliptin (sax' a glip' tin) is an inhibitor of dipeptidyl peptidase-4, which is the major enzyme responsible for the degradation of glucagon-like peptide-1 (GLP-1), an important gastrointestinal hormone (incretin) that increases glucose dependent insulin secretion by the pancreas. By prolonging the effect of GLP-1, saxagliptin increases insulin levels and lowers blood glucose, thereby improving glycemic control in patients with type 2 diabetes. Saxagliptin

FDA approval information for Saxagliptin

Saxagliptin was approved for use in the United States in 2009 and was the second DPP-4 inhibitor introduced into clinical practice. Its current indications are for management of glycemic control in type 2 diabetes used in combination with diet and exercise, with or without other oral hypoglycemic agents or insulin. Saxagliptin is available in tablets of 2.5 and 5 mg under the brand name Onglyza and as a fixed dose combination with metformin under the name Kombiglyze and with dapagliflozin under the name Qtern. The typical dose of saxagliptin in adults is 2.5 to 5 mg once daily. Adverse reactions to saxagliptin are not common, but may include headache, nausea, allergic reactions and rash. Hypoglycemia is uncommon with saxagliptin alone (<1%), but occurs in higher rates when it is combined with other oral hypoglycemic agents. Rare side effects reported with saxagliptin as with other DPP-4 inhibitors include bullous pemphigoid, severe arthralgias, acute pancreatitis and hypersensitivity reactions.

Antidiabetics

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