Rosiglitazone
Contents
- 1 Information about Rosiglitazone
- 2 Mechanism of action of Rosiglitazone
- 3 FDA approval information for Rosiglitazone
- 4 Dosage and administration for Rosiglitazone
- 5 Drug safety alert
- 6 Cost and Coupons - Rosiglitazone
- 7 Reviews for Rosiglitazone
- 8 Articles on Rosiglitazone
- 9 Learn more about Rosiglitazone
- 10 Help WikiMD
Information about Rosiglitazone
Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes.
== Liver safety of Rosiglitazone ==}}}}} Rosiglitazone has been linked to rare instances of acute liver injury.
Mechanism of action of Rosiglitazone
Rosiglitazone (roe" si gli' ta zone) an insulin sensitizing agent that improves glucose control in patients with type 2 diabetes. Like other thiazolidinediones, it is thought to act by engagement of PPAR-? receptors which induce multiple genes involved in glucose and fatty acid metabolism. In clinical trials, rosiglitazone was found to lower blood glucose and HbA1c levels and had additive effects with the sulfonylureas and metformin.
FDA approval information for Rosiglitazone
Rosiglitazone was approved for use in the United States in 1999. While the initial thiazolidinedione – troglitazone – had been associated with high rates of serum aminotransferase elevations and multiple reports of severe liver injury and death from acute liver failure, rosiglitazone was associated with a lower rate of ALT elevations and with only rare instances of clinically apparent liver injury. Rosiglitazone is approved as an adjunct to diet and exercise in the glycemic control of patients with type 2 diabetes.
Dosage and administration for Rosiglitazone
Rosiglitazone is available as 2 and 4 mg tablets generically and under the brand name Avandia and the usual recommended dosage is 4 to 8 mg daily in two divided doses. Rosiglitazone is used as monotherapy as well as in combination with metformin, sulfonylureas or insulin.
Drug safety alert
In 2010, the FDA published a drug safety alert concerning the cardiovascular risks of rosiglitazone and the drug has been withdrawn in many countries of the world, because of these potential long term adverse effects. In the United States, it remains available but is recommended only for patients who are unable to achieve glycemic control with other diabetes medications.
Antidiabetics
- Alpha-Glucosidase Inhibitors
- Incretin-Based Drugs
- Insulin
- Metformin
- Metiglinide Analogues
- Pramlintide
- Sodium Glucose Cotransporter-2 (SGLT-2) Inhibitors
- Sulfonylureas
- First Generation Sulfonylureas
- Acetohexamide
- Chlorpropamide
- Tolazamide
- Tolbutamide
- Second Generation Sulfonylureas
- Gliclazide
- Glimepiride
- Glipizide
- Glyburide (Glibenclamide)
- First Generation Sulfonylureas
- Thiazolidinediones
Cost and Coupons - Rosiglitazone
Reviews for Rosiglitazone
This article is a stub. YOU can help Wikimd by expanding it!

Articles on Rosiglitazone
- UpToDate on Rosiglitazone
- NIH NLH drug info on Rosiglitazone
- Read Wikipedia's article on Rosiglitazone
Learn more about Rosiglitazone
Help WikiMD
Find something you can improve? Join WikiMD as an an editor and help improve this page or others.
WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.
![]() |
Wikimedia Commons has media related to Drugs. |
Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP* |
Quick links: Medicine Portal | Encyclopedia | Gray's Anatomy | Topics | Diseases | Drugs | Wellness | Obesity | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Rosiglitazone">Rosiglitazone</a>
- Individual results may vary for weight loss from our sponsors.