Rosenthal fiber

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Rosenthal fiber

Rosenthal fiber (/roʊˈzɛnθɑːl ˈfaɪbər/) is a type of eosinophilic deposit found in the brain. These fibers are named after the German pathologist Karl Rosenthal, who first described them in 1898.

Etymology

The term "Rosenthal fiber" is derived from the name of the German pathologist Karl Rosenthal, who first identified these fibers. The word "fiber" comes from the Latin "fibra", meaning "a thread or filament".

Description

Rosenthal fibers are elongated, eosinophilic (acidophilic), rod-shaped structures found in the astrocytes of the brain. They are composed of glial fibrillary acidic protein (GFAP) and small heat shock proteins, including alphaB-crystallin and HSP27. These fibers are typically found in various neurological disorders, including Alexander disease, pilocytic astrocytoma, and progressive multifocal leukoencephalopathy.

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