Rolapitant
Rolapitant (pronounced roh-LAP-i-tant) is a medication used in the prevention of chemotherapy-induced nausea and vomiting (CINV). It is classified as a neurokinin 1 receptor antagonist (NK1 antagonist).
Etymology
The name "Rolapitant" is derived from the class of drugs it belongs to, NK1 antagonists. The "-pitant" suffix is common among this class of drugs, indicating their function as antagonists.
Pharmacology
Rolapitant works by blocking the neurokinin 1 receptor, a protein found in the brain that is involved in transmitting signals for nausea and vomiting. By blocking this receptor, Rolapitant can help prevent these symptoms in patients undergoing chemotherapy.
Usage
Rolapitant is typically used in combination with other antiemetic medications to prevent nausea and vomiting caused by chemotherapy. It is administered orally in tablet form.
Side Effects
Common side effects of Rolapitant include fatigue, hiccups, decreased appetite, and dizziness. More serious side effects can include severe allergic reactions.
Related Terms
- Chemotherapy-induced nausea and vomiting (CINV)
- Neurokinin 1 receptor antagonist (NK1 antagonist)
- Neurokinin 1 receptor
- Antiemetic
External links
- Medical encyclopedia article on Rolapitant
- Wikipedia's article - Rolapitant
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