Rocuronium bromide

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Rocuronium bromide (pronunciation: roe-kure-OH-nee-um BROE-mide) is a type of non-depolarizing muscle relaxant used in modern anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Etymology

The name "Rocuronium" comes from the words "rapid onset" and "curare", an arrow poison used by South American indigenous people which causes muscle paralysis. The suffix "-ium" is common in the names of many drugs, particularly those that affect the nervous system.

Pharmacology

Rocuronium bromide acts by competitively binding to nicotinic acetylcholine receptors on the motor end-plate. This binding reduces the effect of acetylcholine, resulting in muscle relaxation.

Clinical Use

Rocuronium bromide is often used in rapid sequence induction (RSI) to facilitate endotracheal intubation. It is also used to provide muscle relaxation for patients undergoing surgery or those who require mechanical ventilation.

Side Effects

Possible side effects of rocuronium bromide include hypotension, tachycardia, and bronchospasm. In rare cases, it can cause anaphylaxis, a severe allergic reaction.

Related Terms

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