Rimantadine

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Information about Rimantadine

Rimantadine is an antiviral agent used as therapy for influenza A. Rimantadine has not been associated with clinically apparent liver injury.

Mechanism of action of Rimantadine

Rimantadine (ri man' ta deen) is a cyclic primary amine that has antiviral and anti-Parkinsonian activities. The antiviral activity of rimantadine is attributed to inhibition of virion uncoating and release of viral RNA in the initial stages of viral replication. Rimantadine is active only against influenza A virus and has no activity against influenza B or other upper respiratory viruses. In addition, resistance to rimantadine with cross reactivity against amantadine can develop rapidly and is now common. The anti-Parkinsonian activity of rimantadine appears to be due to its effects on release of dopamine in the substantia nigra; however, it has not been developed or approved for this indication.

Clinical use of Rimantadine

Rimantadine is indicated for treatment or prevention of influenza A and was approved for this use in the United States in 1993. Rimantadine is available as tablets of 100 mg and as syrup (50 mg/5 mL) in generic forms and under the brand name of Flumadine. The recommended dose for influenza in adults is 100 mg twice daily for 5-7 days; rimantadine is also administered as prophylaxis starting as soon as possible after close personal exposure.

Side effects of Rimantadine

Side effects may include anxiety, dizziness, ataxia, confusion, fatigue, headache, insomnia, dry mouth and gastrointestinal upset. Drugs for HIV Infection, in the Subclass Antiretroviral Agents

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