Retinoic acid syndrome

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Retinoic Acid Syndrome

Retinoic Acid Syndrome (pronunciation: reh-tin-OH-ic AH-sid SIN-drome) is a potentially severe complication that can occur in patients undergoing treatment with retinoic acid, a form of vitamin A used in the treatment of acute promyelocytic leukemia (APL).

Etymology

The term "Retinoic Acid Syndrome" is derived from the name of the drug, retinoic acid, which can cause the syndrome, and the Greek word "syndrome", which means "running together" of symptoms.

Definition

Retinoic Acid Syndrome is characterized by fever, respiratory distress, pulmonary infiltrates, and pleural or pericardial effusions, with or without leukocytosis. It is typically associated with the use of all-trans retinoic acid (ATRA), a medication used to treat APL.

Symptoms

Symptoms of Retinoic Acid Syndrome may include:

  • Fever
  • Difficulty breathing
  • Rapid weight gain
  • Swelling in the lower legs or hands
  • Unusual tiredness or weakness

Treatment

Treatment typically involves discontinuation of ATRA and administration of dexamethasone. In severe cases, hospitalization may be required.

Related Terms

External links

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