Reelin

From WikiMD.org
Jump to navigation Jump to search

Reelin

Reelin (pronounced: ree-lin) is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell-cell interactions.

Etymology

The term "Reelin" is derived from the word "reeler", a term used to describe the phenotype of a mutant mouse strain that was discovered to have a unique 'reeling' gait due to a mutation in the gene encoding this protein.

Function

Reelin plays a crucial role in neuronal migration and positioning in the developing brain. It is secreted by pioneer neurons and binds to receptors on migrating cells, signaling them to stop migrating and start differentiating. This process is essential for the proper formation of laminated brain structures.

Related Terms

  • Extracellular Matrix: The extracellular matrix is a three-dimensional network of extracellular macromolecules, such as collagen, enzymes, and glycoproteins, that provide structural and biochemical support to surrounding cells.
  • Glycoprotein: Glycoproteins are proteins that have sugar molecules attached, which can help them to function in the body.
  • Neuronal Migration: Neuronal migration is the method by which neurons travel from their origin or birthplace to their final position in the brain.
  • Pioneer Neurons: Pioneer neurons are the first neurons to migrate to a specific region of the developing brain and establish a scaffold that later neurons will follow.

See Also

External links

Esculaap.svg

This WikiMD dictionary article is a stub. You can help make it a full article.


Languages: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski