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[{intro}} Ramipril is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and heart failure.

Liver safety of Ramipril

Ramipril is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.

Mechanism of action of Ramipril

Ramipril (ra' mi pril) is an ACE inhibitor widely used in the therapy of hypertension, heart failure and for reduction in risk of myocardial infarction and stroke. Like other ACE inhibitors, ramipril inhibits the conversion of angiotensin I, a relatively inactive molecule, to angiotensin II which is the major mediator of vasoconstriction and volume expansion induced by the renin-angiotensin system. Other enzymes besides that which converts angiotensin I to II may also be inhibited, which may account for some of the side effects of ramipril and other ACE inhibitors.

FDA approval information for Ramipril

Ramipril was approved for use in the United States in 1991 and is available in 1.25, 2.5, 5 and 10 mg capsules or tablets in generic forms and under the trade name Altace.

Dosage and administration for Ramipril

In adults, ramipril is usually started in a dose of 2.5 mg daily and then adjusted based upon blood pressure response and tolerance to 10 to 20 mg daily. It is typically used long term.

Side effects of Ramipril

Common side effects include dizziness, fatigue, headache, cough, gastrointestinal upset and skin rash.

Common ACE inhibitors include the following:

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Articles on Ramipril

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