Protein conformation
Protein Conformation
Protein conformation refers to the three-dimensional shape of a protein molecule. The conformation of a protein is determined by its amino acid sequence, or primary structure, and its environment.
Pronunciation
Protein Conformation: /ˈproʊtiːn ˌkɒnfɔːrˈmeɪʃən/
Etymology
The term "protein conformation" is derived from the Greek word "proteios", meaning "primary" or "in the lead", and the Latin word "conformare", meaning "to shape".
Related Terms
- Primary structure: The sequence of amino acids in a protein.
- Secondary structure: The local folded structures that form within a protein.
- Tertiary structure: The overall three-dimensional shape of a protein.
- Quaternary structure: The arrangement of multiple folded protein molecules in a multi-subunit complex.
- Protein folding: The process by which a protein structure assumes its functional shape or conformation.
- Protein structure prediction: The prediction of the three-dimensional structure of a protein from its amino acid sequence.
- Protein–protein interaction: The physical contacts of high specificity established between two or more protein molecules as a result of biochemical events and/or electrostatic forces.
Protein Conformation
Protein conformation is crucial for the function of proteins. The shape of a protein determines its function, and changes in the conformation can alter the function or render the protein inactive. Protein conformation is influenced by various factors, including the protein's amino acid sequence, the environment, and interactions with other molecules.
Proteins can adopt a variety of conformations, but only a few of these will be stable and functional. The process by which a protein adopts its stable, functional conformation is known as protein folding. Misfolding of proteins can lead to a variety of diseases, including Alzheimer's disease and Parkinson's disease.
External links
- Medical encyclopedia article on Protein conformation
- Wikipedia's article - Protein conformation
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