Protein c

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Protein C

Protein C (pronounced: pro-teen see) is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.

Etymology

The term "Protein C" was coined in 1960 by Seegers, Johnson, and Fell, who observed an unidentified protein (which they named Protein C) that appeared to participate in the blood coagulation process.

Function

Protein C is a major physiological anticoagulant. It is a vitamin K-dependent serine protease enzyme that is activated by thrombin into activated Protein C (APC). The activated form (with protein S as a cofactor), degrades Factor Va and Factor VIIIa, reducing the amount of thrombin generated.

Related Terms

Deficiency

Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease. It was first described in 1981. The disease belongs to a group of diseases known as inherited thrombophilia.

See Also

External links

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