WikiMD is world's largest health encyclopedia with
28,588 pages, 3,993,896 edits & 34,362,068 views.
Promethazine
Information about Promethazine
Promethazine is first generation antihistamine that belongs to the phenothiazine class and is used predominantly as an antiemetic to treat nausea and vomiting and prevent motion sickness.
Liver safety of Promethazine
Despite its phenothiazine structure, promethazine has not been linked to instances of clinically apparent acute liver injury.
Mechanism of action of Promethazine
Promethazine (proe meth' a zeen) is a first generation antihistamine that is used widely to treat and prevent nausea and to a lesser extent to treat allergy symptoms and as a mild sedative. Promethazine belongs to the phenothiazine class of antihistamines and is a potent antiemetic. Because of its sedating effects, promethazine is also used for anxiety, tension and as a mild sleeping aid.
FDA approval information for Promethazine
Promethazine was approved for use in the United States in 1957 and continues to be widely used with more than 10 million prescriptions filled yearly.
== Dosage and administration for Promethazine ==Promethazine is available in multiple forms including tablets, capsules, syrups, suppositories and liquid solution for injection generically and under the brand name Phenergan. Unlike other antihistamines, promethazine is not available over-the-counter. Current indications include nausea, preoperative sedation, nighttime sedation, rhinitis and allergic symptoms, cough and respiratory symptoms, and treatment and prevention of motion sickness. The typical recommended dose in adults is 12.5 to 25 mg orally or by rectal suppository, which can be repeated every 4 to 6 hours as necessary.
Side effects of Promethazine
Common side effects include excessive sedation, impairment of motor function, confusion, dizziness, extrapyramidal symptoms, blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation and headache. Antihistamines can worsen urinary retention and glaucoma.
First Generation Antihistamines
- Brompheniramine
- Carbinoxamine
- Chlorcyclizine
- Chlorpheniramine
- Clemastine
- Cyclizine
- Cyproheptadine
- Dexbrompheniramine
- Dexchlorpheniramine
- Dimenhydrinate
- Diphenhydramine
- Doxylamine
- Hydroxyzine
- Meclizine
- Phenyltoloxamine
- Promethazine
- Triprolidine
Second Generation Antihistamines
Cost and Coupons - Promethazine
- GoodRx compare cost & coupons for Promethazine
- Find the lowest cost of Promethazine
- Search for Coupons for Promethazine
Reviews for Promethazine
Learn more about Promethazine
Latest research (Pubmed)
External links
WikiMD needs you!
This WikiMD article Promethazine is a stub.
If you are a healthcare professional familiar with the topic Promethazine, or
A subject matter expert or authority on Promethazine, you can help us.
About | Mission | Paid editors welcome!
Promethazine is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever! |
---|
Medicine: Health - Encyclopedia - Topics - Diseases - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers |
Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP* |