Proguanil
Proguanil
Proguanil (/proʊˈɡwænɪl/), also known as chloroguanide and sold under the brand names Paludrine and Malarone among others, is a medication used to treat and prevent malaria. It is often used together with atovaquone to increase its effectiveness.
Etymology
The name "Proguanil" originates from its chemical structure, which is a biguanide compound that is prodrug of cycloguanil. The prefix "pro-" indicates that it is a precursor to the active drug, while "guanil" refers to its guanidine structure.
Usage
Proguanil is primarily used in combination with atovaquone for the prevention and treatment of malaria. It works by inhibiting the enzyme dihydrofolate reductase, which is necessary for the reproduction of the malaria parasite.
Side Effects
Common side effects of proguanil include nausea, vomiting, and abdominal pain. In rare cases, it can cause more serious side effects such as anemia or hepatitis.
Related Terms
See Also
External links
- Medical encyclopedia article on Proguanil
- Wikipedia's article - Proguanil
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