WikiMD


COVID-19 portal | Vitamin D | CDC | Vaccine | Keto | W8MD Diet

WikiMD is world's largest health encyclopedia with
28,548 pages, 3,991,527 edits & 34,308,805 views.

Unbiased health & wellness info for free & for all!

Procarbazine

From WikiMD
Jump to navigation Jump to search


Information about Procarbazine

Procarbazine is an orally administered alkylating agent used in combination with other anti-neoplastic agents in the therapy of Hodgkin’s disease and malignant melanoma

Procarbazine
Procarbazine

Liver safety of Procarbazine

Procarbazine therapy has been associated with serum enzyme elevations during therapy and with rare cases of idiosyncratic, clinically apparent acute liver injury.

Mechanism of action of Procarbazine

Procarbazine (proe kar' ba zeen) is a methylhydrazine derivative which is activated in the liver to highly reactive alkylating intermediates.  These intermediates methylate DNA which causes inhibition of DNA, RNA and protein synthesis and cell death. 

FDA approval information for Procarbazine

Procarbazine was approved for use in the United States in 1969 and it remains a commonly used agent in the treatment of Hodgkin’s and non-Hodgkin’s lymphomas and brain cancer.  Procarbazine is rarely used alone, but is found in common cancer chemotherapeutic regimens such as MOPP (mechlorethamine, vincristine [oncovin], procarbazine and prednisone), COPP (cyclophosphamide, vincristine [oncovin], procarbazine and prednisone), and PCV (procarbazine, lomustine [CCNU], vincristine). 

Dosage and administration for Procarbazine

Procarbazine is available as tablets of 50 mg generically and under the brand name Matulane.  It is typically given in monthly or every other month cycles of 10 to 14 days in a dose of 100 mg per meter squared body surface area. 

Side effects of Procarbazine

  • Common side effects are alopecia, anoxia, nausea, vomiting, headache, peripheral neuropathy, and flu-like illness.

Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ

Learn more about Procarbazine

Latest research (Pubmed)

PubMed
Wikipedia

External links


edit 

WikiMD needs you!

This WikiMD article Procarbazine is a stub.
If you are a healthcare professional familiar with the topic Procarbazine, or
A subject matter expert or authority on Procarbazine, you can help us.
About | Mission | Paid editors welcome!

Procarbazine is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever!
Medicine: Health - Encyclopedia‏‎‏‎ - Topics‏‎ -‏‎ Diseases‏‎ - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity‏‎ - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*