Proadifen
Proadifen
Proadifen (pronunciation: pro-uh-DIE-fen) is a pharmaceutical drug that is known for its inhibitory effects on various cytochrome P450 enzymes. It is also known as SKF-525A.
Etymology
The term "Proadifen" is derived from its chemical name, Propyl-adipate fentanyl. The "SKF" in its alternative name, SKF-525A, refers to the pharmaceutical company that first synthesized it, Smith, Kline & French Laboratories.
Pharmacology
Proadifen is a non-selective, competitive inhibitor of the cytochrome P450 enzyme system. It inhibits the metabolism of various drugs by competing for the active site of P450 enzymes. This can lead to increased plasma concentrations of drugs metabolized by these enzymes, potentially enhancing their therapeutic effects but also increasing the risk of adverse effects.
Clinical Use
Proadifen has been used in research to study drug metabolism and interactions. It is not currently approved for therapeutic use in humans.
Related Terms
- Cytochrome P450: A group of enzymes involved in drug metabolism.
- Enzyme Inhibitor: A substance that reduces the activity of an enzyme.
- Drug Metabolism: The process by which the body breaks down and converts medication into active chemical substances.
- Pharmacokinetics: The study of how an organism affects a drug, including absorption, distribution, metabolism, and excretion.
External links
- Medical encyclopedia article on Proadifen
- Wikipedia's article - Proadifen
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